Humane World for Animals

Tell the FDA: Please quickly implement changes to make it clear that animal testing is not required!

Every day, countless dogs, monkeys, rats and other animals endure unimaginable suffering in distressing and often painful experiments because of an ineffective drug approval process. These animals spend their entire lives in barren laboratory settings, are forced to ingest—or are injected with—potentially toxic substances, suffer through various other invasive procedures and are typically killed when the tests finally end. What’s worse is that a staggering 90% of drugs deemed safe and effective in animal tests ultimately fail in human trials.  

But there’s good news—the U.S. Food and Drug Administration just released a rule which seeks to remove outdated references to animal testing in their regulations, making it clear that that companies do not have to carry out animal tests to get their drugs approved. We need your help to ensure that the agency quickly implements these changes!

Unfortunately, FDA regulations for pharmaceutical companies have long been unclear and continued to emphasize using animals for drug testing—leading companies to believe that animal testing is legally required as part of the drug approval process. This new rule could finally change that.

We need your voice to make a difference for the countless animals suffering in labs. Please take a moment to contact the FDA!

TAKE ACTION 

Please use the form to send a message to the FDA urging them to quickly implement their rule to ensure that drug companies know they can use non-animal alternatives instead of animal tests whenever possible! 

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Dear Commissioner,  

I am writing to thank the U.S. Food and Drug Administration for releasing its direct final rule that makes it clear to drug companies that they can and should submit data from innovative non-animal technologies whenever possible.   

Animal tests are expensive and time consuming yet are not reliable predictors of how humans respond to drugs. In fact, approximately 90% of drugs deemed safe and effective in animal tests ultimately fail in human trials, with almost half of these failures attributed to unforeseen toxic reactions not observed in animals.  

In contrast, animal tests are no match for cutting-edge non-animal technologies like advanced human cell-based systems and computational models. Because they’re based on how the human body works, these sophisticated methods can provide more accurate and efficient insights into how drugs affect people. It’s simply better, more advanced science—and it doesn’t harm animals.  

The suffering inherent in animal testing cannot be overstated. At one lab, a Humane World for Animals investigator watched as several beagles who experienced fevers, tremors, rapid heart rates, labored breathing and unsteadiness following a high dose of a test substance were ordered to be dosed again, despite the dramatically harmful effects of the test substance. In another instance, the investigator comforted a dog as he lay dying on his kennel floor—hypersalivating, trembling, vomiting, moaning and unable to stand. The dog was not euthanized by the veterinarian until the following day. This is just one example of what is happening to animals in laboratories around the country on a daily basis.   

As such, I strongly support FDA’s direct final rule which makes it clear to drug companies that animal testing is not required for drug approvals, and I urge the agency to implement this rule as quickly as possible.  

Thank you for your consideration.

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